Melatonin is a hormone that is the Pinealocytes in the pineal gland part of the midbrain produced from serotonin. The hormone regulates the day night cycle of the human body. Chemically, the melatonin is an alkaloid tryptamine structure. The hormone is a natural non addicting hormone supplement that helps in sleeping. In U.S., millions of people take it in order to melatonin hormone supplement to get a good night’s sleep as they can’t sleep properly due to various reasons. With stimulation from natural light into the eye, the synthesis of melatonin is slowed down in the night and at night the hormone released increasingly into the blood and affects sleep. Melatonin is naturally produced in the body in response to the sensitivity of light. The hormone is effective in the treatment of insomnia and helps to combat jet lag.
2. Melatonin Metabolism
Melatonin is a metabolite of tryptophan metabolism. The hormone is produced in the pineal gland in the gut and in the retina of the eye and central pulsatile release under the influence of darkness. The concentrations of melatonin raises in the night by a factor of ten, the maximum is reached around 3 in the morning with seasonally changing rhythms. The production is hampered by daylight. The significance of melatonin for jet lag and shift lag is well recognized but the administration of melatonin is yet controversial in the context. With the coordination of circadian rhythmic process in the body, it works as timer. Melatonin induced deep sleep is a stimulant for the production of growth hormone somatotropin. These chronic disorders can cause premature somatopause. Melatonin is also effective as an anti-oxidant which can’t be used therapeutically, especially when taking eight of melatonin. More than ever, decrease in the melatonin level in the blood causes sleep disorder or hindrances in the sleep wake cycle.
3. Melatonin Benefits
Melatonin helps eases insomnia, jet lag and protects cells from free radical damage. The hormone also improves immune system, prevents cancer and prolongs life. What’s more, many studies have shown that melatonin’s multi-faceted effects may improve treatment results in cancer patients and prolonged their lives. Other benefits of melatonin include protecting the nervous systems against degenerative diseases. The hormone works with your biological clock by telling your brain when it is the time to sleep. Additionally, it may also help in normalizing cholesterol levels and keeps your heart strong. Melatonin may also play a significant role in the treatment of Down syndrome and Alzheimer’s. The hormone is effective in rheumatic disease as it normalizes the immune status. Moreover, it increases the weight of thymus gland besides increasing the activity of Thymusdrüsenzellen.
Melatonin is a strong and versatile antioxidant produced in our body. The hormone safeguards both lipids and proteins and can check some of the most harmful free radicals in the body including hydroxyl radicals and hydrogen peroxide. Melatonin easily diffuses into all cells and even crosses the blood brain hindrance to safeguards the delicate brain. The levels of melatonin decreases with the increasing age thus leaving older adults with limited anti-oxidants protection against conditions related with oxidative stress, especially neurodegenerative diseases. Melatonin supplements may help older adults increase their antioxidant protection against some of the most harmful diseases of aging.
5. Melatonin and Viruses
Melatonin supplements can compensate the damage to corticosteroids chronic stress. An overproduction of corticosteroids can shrink the thymus gland. The intake of zinc can also improve immune system and enhance the immune response. Melatonin increases the body’s ability to recognize cancer cells and damage them. The hormone also protects body against cancer promoting substances and has been used recently to treat several viral infections.
6. Melatonin and Cancer
Studies have shown that the people suffering with different cancers such as lung cancer, kidney cancer, breast cancer, prostate cancer and liver cancer species have a low melatonin level. The administration of oral melatonin (10 to 50 mg [per day) increases the effectiveness of other therapies. Melatonin is an immune modulator that increases the survival of most cancer patients. Few cancer patients are now taking melatonin, a neurohormone immunomodulatory activities, as part of a comprehensive, non-toxic cancer treatment. The cone shaped pineal gland is a small yet significant gland in the brain that produces melatonin. Melatonin supplement improves circadian rhythms, which decline or stop with age. The abolishment of melatonin’s circadian rhythm increases the aging process, cut down the lifespan, and an increase in spontaneous tumors takes place. If the defense system is compromised due to interrupted rhythms, tumors grow 2 to 3 times faster.
7. Melatonin and Hair Loss
The outcomes of pilot study of the Friedrich-Schiller University in Jena – The first evidence that melatonin may positively influence the external application – the hair growth in humans. But the hormonal effect of melatonin still remains doubtful and it is supposed that melatonin stimulates the beginning of the anagen phase in the hair growth cycle. In relation to placebo, the dummy external use of melatonin resulted in a considerable increase in detectable in anagen hairs Hinterhauptsbereich androgenetical of women with hair loss. However, in women having diffuse hair loss pattern, the influence of melatonin considerably increased the number of anagen hairs in the frontal area (Circadian rhythm sleep disorder).
8. Melatonin and Blood Cell
Melatonin safeguards and restores normal blood cell production owing to the toxicity of conventional treatments, a profile shared with FDA approved drugs Neupogen, a granulocyte colony-stimulating factor (G-CSF) and Leukine, a granulocyte-macrophage colony stimulating factor (GM-CSF). The application of melatonin along with low dose interleukin-2 (IL-2) neutralizing therapy induced lymphopenia, a decrease in the number of lymphocytes in the peripheral circulation of cancer patients. The researchers have discovered the most effective way to supplement the anticancer activity of low dose IL-2 is not co-management with other cytokines, but co-supplementing with immunomodulatory neurohormone melatonin (Lissoni et al. 1994a). This is optimistic news for a subset of cancer patients, because melatonin has been found to cause tumor deterioration in neoplasms nonresponsive to IL-2 (Maestroni 1999).
9. Melatonin Research
The researchers have discovered the most effective way to supplement the anticancer activity of low dose IL-2 is not co-management with other cytokines, but co-supplementing with immunomodulatory neurohormone melatonin (jet lag) (Lissoni et al. 1994a). This is optimistic news for a subset of cancer patients, because melatonin has been found to cause tumor deterioration in neoplasms nonresponsive to IL-2 (Maestroni 1999). The Department of Radiation Oncology of the San Gerardo Hospital (Milan) developed the following protocol for 80 patients with advanced metastatic tumors. The patients were selected randomly to receive 3 million IU IL-2, 6 days a week for 4 weeks or IL-2 mg plus 40 per day for melatonin. A complete response was achieved in 3 of 41 patients treated with IL-2 plus melatonin and in none of the patients, only IL-2. A partial response in 8 of 41 patients treated with IL-2 plus melatonin and in 1 of 39 patients treated with IL-2. Tumor deterioration rate was considerably higher in patients with IL-2 and melatonin compared to those having survival at 1 year was higher in patients with IL-2 and melatonin than in the IL-2 group. Lymphocytic populations were considerably higher when supplemented by melatonin treatment and thrombocytopenia occurred less often.
10. Melatonin and Brain
Still today, the treatment of non resectable brain metastases is not available. Owing to the cytostatic action of melatonin’s ability (to destroy the growth of cells) and its anticonvulsant activity, melatonin (pineal gland) might be effective in the treatment of brain metastases. In studies to test the theory, it was found that 50 patients with incurable brain metastases got supportive care or supportive care in addition to 20 mg of melatonin nightly. The chances of brain tumor progression and survival rates at 1 year were higher in patients treated with melatonin in comparison to those who got only supportive care (Lissoni et al. 1994b, 1996). While melatonin was not in a position to the progression of advanced metastatic disease, the hormone enhanced the performance status of patients.
11. Melatonin and Breast Cancer
Low melatonin levels significantly increases the chances of breast cancer. A decrease in the production of melatonin increases the production of estrogen. The night temperatures and the production of melatonin slow down production of estrogen in the body and reduce the growth of human breast cancer cells. On the other hand, exposure to light at night decreases melatonin production and increases the lifetime growth estrogen levels, a sequence which may increase the risk of breast cancer. In fact, it has been found in two recent studies that women who work night shifts are risked of breast cancer up to 60%. Blind women have a considerably lower risk (36% less) of breast cancer in comparison to normal sighted women, thanks to the consistently higher melatonin (Kliukiene et al. 2001). Women who were just like visually impaired people realized no defensive effects for breast cancer.
12. Melatonin Production
When it supplemented from outside the amount of melatonin that it requires to secure energy supply at the cellular levels again, it will be helpful. Melatonin is readily absorbed in the digestive tract (gastrointestinal tract is found in the young body to increased melatonin concentration) and enters the blood the bloodstream into body cells, and in the endocrine glands and also in the pineal gland itself, where it again performs its main role that is to secure energy supplies. The production of injurious pyrophosphate is slowed down and replaced by high-energy ATP. The energy produced let the mitochondria to renew and recommence its original function again. Also, the pineal gland itself will have enough energy to do its normal function and increase its own production of melatonin. Buy Melatonin, Order Melatonin, Melatonin natural sleep Pills, Serotonin, Melatonin supplements, Sleep hormone, sleep aid.
13. Melatonin and Sleep
Melatonin is a natural hormone that regulates the inner clock of your body and is a part of our sleep-wake cycle. The hormone activates certain chemical receptors in the brain which causes sleep. It’s a compound that helps body to control sleep (Sleep disorder) and other physiological rhythms. It has been found in many studies that melatonin can be effective in easing the jet lag, especially for crossing five or more times zones when travelling east. The hormone is supposed to be quite safe. Also, it is worth mentioning that this naturally occurring hormone is used by increasing number of people as sleep aid. Melatonin supplements can ease certain sleep disorders including jet lag.
14. Melatonin References
l. Domingo M, Role of melatonin in health and disease. Clin Endocrinol 1995.
2. O’Brien IAD, Lewin IG, O’Hare JP, et al Abnormal circadian rhythm of melatonin.
3. Tetsuo M, Polinsky RJ Melatonin excretion in patients with orthostatic hypotension.
4. Li Y, Jiang DH, Wang ML Rhythms of serum melatonin in patients with spinal lesions.
5. Kneisley, Moskowitz spinal lesions disrupt the rhythm in human melatonin excretion.
6. Folkard S, Arendt J, Aldhouse Melatonin stabilizes sleep onset time in a blind man.
7. Arias J, Melean E, Effect of melatonin on lymphocyte proliferation and production
8. Touitou Y (July 2001). “Human aging and melatonin”. Exp. Gerontol.
15. Melatonin information
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